The actors and actresses under contract to the studio included Greta Garbo, Clark Gable, Spencer Tracy and Joan Crawford, as well as an impressive list of child stars: Elizabeth Taylor, Mickey Rooney and Judy Garland. The sudden death of Irving Thalberg in 1936 shocked the industry, and a new million-dollar Administration Building built on the lot was dedicated in his memory two years later.

Mayer continued to manage the studio, making such notable movies as GRAND HOTEL, THE THIN MAN, MUTINY ON THE BOUNTY and The WIZARD OF OZ. Production Chief Dore Schary gradually assumed power, replacing Mayer in 1951. Even though MGM added television production capabilities, it declined steadily through the 1960's.

The studio was sold to Kirk Kerkorian in the 1970's and much of the lot was sold. An auction was held on the spot where Dorothy had once skipped down the Yellow Brick Road. Lot #2, where SINGIN’ IN THE RAIN, NATIONAL VELVET and GIGI were made, was dismantled. Lot #3 was sold as land for housing. The monkey farm, plant nursery and antique car lot were sold for commercial development.